Researcher Database
SUGIMURA Satoshi
| ■Faculty | Institute of Global Innovation Research | |||
| ■Position | Professor | |||
Last Updated :2025/09/05
Activity information
Name and contact details
Name
スギムラ サトシ, 杉村 智史, SUGIMURA Satoshi
Affiliation / Position
Institute of Global Innovation Research, Professor
Other affiliation
- Field Science Center
- Organization for Promotion of Tenure-track System
- Institute of Agriculture Division of Science of Biological Production
- Graduate School of Agriculture
- Faculty of Agriculture
Research History
- -
東京農工大学 テニュアトラック推進機構 特任准教授
From 01 Nov. 2013 - -
日本学術振興会海外特別研究員 アデレード大学
From 01 Apr. 2012, To 31 Oct. 2013 - -
独立行政法人家畜改良センター
From 01 Apr. 2009, To 31 Mar. 2012 - -
日本学術振興会特別研究員(PD) 東北大学
From 01 Apr. 2008, To 31 Mar. 2009
Education
- Tohoku University
Graduate School, Division of Agriculture
応用生命科学専攻
To Mar. 2008, completed, doctor course
Degree
Current state of research and teaching activities
Research Areas
Grants-in-Aid for Scientific Research
- 基盤研究（C）
着床前胚発生における微小核形成へのミトコンドリア機能の関与
From 2024, To 2024 - 基盤研究（C）
着床前胚発生における微小核形成へのミトコンドリア機能の関与
From 2023, To 2023 - 基盤研究(B)
ウシ着床前胚における染色体自己修復の理解
From 2022, To 2024 - 挑戦的研究（萌芽）
受精胚の染色体異常に関連して発現する動的バイオマーカーの網羅的探索
From 2021, To 2022 - 基盤研究(C)
異種の生殖器官および生殖細胞をマウスで再生する技術の開発
From 2020, To 2020 - 基盤研究(C)
異種の生殖器官および生殖細胞をマウスで再生する技術の開発
From 2019, To 2019 - 基盤研究(C)
異種の生殖器官および生殖細胞をマウスで再生する技術の開発
From 2018, To 2018 - 基盤研究(C)
ウシ卵母細胞の機能的完全性を裏打ちする卵丘細胞の分子生物学的特徴
From 2018, To 2021 - 基盤研究(C)
被災雄牛における継世代影響評価系の構築と解析
From 2015, To 2017 - 若手研究(B)
EGFRシグナル伝達系の活性化増強機構の解明によるウシ卵子の発生能向上
From 2015, To 2017
Papers
- High expression of serine protease, Brachyurin in the posterior midgut of black soldier fly (Hermetia illucens) during horse dropping processing
Wakuda, Megumi; Sakamoto, Takuma; Tanaka, Akane; Sugimura, Satoshi; Higashiura, Yuki; Nakazato, Takeru; Bono, Hidemasa; Tabunoki, Hiroko
BMC RESEARCH NOTES
SPRINGERNATURE
29 Jun. 2024, Research paper (scientific journal), joint, 17, 1, DOI(公開)(r-map) - Antioxidant sericin averts the disruption of oocyte-follicular cell communication triggered by oxidative stress
Khatun, Hafiza; Yamanaka, Ken-ichi; Sugimura, Satoshi
MOLECULAR HUMAN REPRODUCTION
OXFORD UNIV PRESS
Antioxidants are free radical scavengers that increase oocyte quality and improve female fertility by suppressing oxidative stress. However, the related mechanisms remain unclear. The present study was designed to examine whether a reduction of oxidative stress from using the antioxidant sericin led to expanded cumulus cell (CC)-oocyte communication and oocyte developmental acquisition in a bovine model. We found that cumulus-oocyte complexes (COCs) matured in the presence of sericin showed a significantly increased oocyte meiotic maturation rate (P < 0.01) and accelerated subsequent blastocyst formation, as more blastocysts were found at the hatched stage (P < 0.05) compared to that in the control group. In contrast to the control group, sericin suppressed H2O2 levels in COCs, resulting in a markedly enhanced CC-oocyte gap junction communication index and number of transzonal projections, which were preserved until 18 h of oocyte maturation. These findings indicate that sericin reduces disruption of oocyte-follicular cell communication induced by oxidative stress. Sericin consistently increased intra-oocyte glutathione (GSH) levels and reduced oocyte H2O2 levels (P < 0.05), both of which were ablated when GSH synthesis was inhibited by buthionine sulfoximide (an inhibitor of GSH synthesis). Furthermore, the inhibition of GSH synthesis counteracted the positive effects of sericin on subsequent embryo developmental competence (P < 0.01). Intra-oocyte GSH levels were positively associated with blastocyst development and quality. These outcomes demonstrate new perspectives for the improvement of oocyte quality in assisted reproductive technology and may contribute to developing treatment strategies for infertility and cancer.
01 Feb. 2024, Research paper (scientific journal), joint, 30, 2, 1360-9947, DOI(公開)(r-map) - Direct cleavage during the first mitosis is a sign of abnormal fertilization in cattle
Suzuki, Ryosuke; Yao, Tatsuma; Okada, Mai; Nagai, Hiroki; Khurchabilig, Atchalalt; Kobayashi, Junichi; Yamagata, Kazuo; Sugimura, Satoshi
THERIOGENOLOGY
ELSEVIER SCIENCE INC
Direct cleavage, a type of abnormal cleavage in which one zygote divides into three or more blastomeres, has been reported in mammals. The incidence of direct cleavage increases in zygotes with three or more pronuclei (multi-PN) and those showing abnormal pronuclei migration. However, there are few reports on the relationship between pronuclei and direct cleavage, and the effects of these relationships on subsequent embryogenesis have not been clarified. It is difficult to observe pronuclei under visible light, especially in bovine zygotes, because of abundant dark lipid droplets in the cytoplasm. We visualized pronuclei by removing lipid droplets from bovine zygotes and analyzed the relationship between the number of pronuclei and direct cleavage using time-lapse cinematography. The direct cleavage rate of multi-PN zygotes was 78.6%, which was significantly higher than that of zygotes with one pronucleus (1 PN, 0.0%) and two pronuclei (2 PN, 8.2%). Observation of pronuclei migration in 2 PN zygotes showed that 3.1% of 2 PN zygotes had non-apposed pronuclei. The direct cleavage rate of zygotes with non -apposed pronuclei was 66.7%, which was significantly higher than that of zygotes with apposed pro -nuclei (6.4%). Among multi-PN zygotes, the proportions of zygotes with apposed pronuclei and non -apposed pronuclei were 37.5% and 64.3%, respectively. The direct cleavage rate of multi-PN zygotes with non-apposed pronuclei was 100.0%, which was significantly higher than that of zygotes with apposed pronuclei (40.0%). Three-dimensional live-cell imaging of bovine zygotes injected with the mRNA-encoding histone H2B-mCherry showed that the direct cleavage rates of 2 PN and multi-PN zy-gotes bypassing syngamy were 63.2% and 75.5%, respectively. These rates were significantly higher than that of 2 PN and multi-PN zygotes that underwent syngamy (5.6% and 20.0%, respectively). Regardless of the number of pronuclei, a high frequency of direct cleavage was observed in zygotes in which the pronuclei did not migrate inward the cytoplasm and bypassed syngamy. These results suggest that abnormal fertilization such as multi-PN and migration error of pronuclei in cattle is the primary reason for direct cleavage during the first mitosis. Assessment of direct cleavage during the first mitosis allows exclusion of embryos with abnormal fertilization and may contribute to in vitro produced embryo transfer success.(c) 2023 Elsevier Inc. All rights reserved.
01 Apr. 2023, Research paper (scientific journal), joint, 200, 0093-691X, DOI(公開)(r-map), 96, 105 - Micronucleus formation during early cleavage division is a potential hallmark of preimplantation embryonic loss in cattle
Yao, Tatsuma; Ueda, Akane; Khurchabilig, Atchalalt; Mashiko, Daisuke; Tokoro, Mikiko; Nagai, Hiroki; Sho, Tei; Matoba, Satoko; Yamagata, Kazuo; Sugimura, Satoshi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
ACADEMIC PRESS INC ELSEVIER SCIENCE
In assisted reproductive technology (ART)-derived embryos of non-rodent mammals, including humans and cattle, chromosome segregation errors are highly likely to occur during early cleavage division, resulting in aneuploidy, including mosaicism. However, the relationship between chromosomal segre-gation errors during early cleavage and subsequent embryonic development has not been detailed in these mammals. In the present study, we developed non-invasive live-cell imaging of chromosome segregation dynamics using a histone H2B-mCherry mRNA probe in bovine preimplantation embryos. Chromosome segregation errors in early cleavage affected blastocyst formation. Especially, embryos that underwent abnormal chromosome segregation (ACS) with multiple or large micronucleus formation rarely developed into blastocysts. Embryos with the severe ACS had prolonged cell cycle duration. After transfer of blastocysts with live-cell imaging of chromosome segregation to ten cows, six became pregnant and four of them gave full-term offspring. Interestingly, two of them were derived from blastocysts with ACS. Hence, chromosomal segregation errors with micronucleus formation during early cleavage can be a fatal hallmark of preimplantation embryogenesis in cattle. This technique has shown potential for understanding the relationship between chromosome segregation error and subsequent embryo development, and for selecting viable ART-derived embryos for medical and livestock production.(c) 2022 Elsevier Inc. All rights reserved.
30 Aug. 2022, Research paper (scientific journal), joint, 617, 0006-291X, DOI(公開)(r-map), 25, 32 - Effects of Selenium Supplementation on Rumen Microbiota, Rumen Fermentation, and Apparent Nutrient Digestibility of Ruminant Animals: A Review
Hendawy, Amin Omar; Sugimura, Satoshi; Sato, Kan; Mansour, Mohamed Mohsen; Abd El-Aziz, Ayman H.; Samir, Haney; Islam, Md. Aminul; Bostami, A. B. M. Rubayet; Mandour, Ahmed S.; Elfadadny, Ahmed; Ragab, Rokaia F.; Abdelmageed, Hend A.; Ali, Amira Mohammed
FERMENTATION-BASEL
MDPI
Enzymes excreted by rumen microbiome facilitate the conversion of ingested plant materials into major nutrients (e.g., volatile fatty acids (VFA) and microbial proteins) required for animal growth. Diet, animal age, and health affect the structure of the rumen microbial community. Pathogenic organisms in the rumen negatively affect fermentation processes in favor of energy loss and animal deprivation of nutrients in ingested feed. Drawing from the ban on antibiotic use during the last decade, the livestock industry has been focused on increasing rumen microbial nutrient supply to ruminants through the use of natural supplements that are capable of promoting the activity of beneficial rumen microflora. Selenium (Se) is a trace mineral commonly used as a supplement to regulate animal metabolism. However, a clear understanding of its effects on rumen microbial composition and rumen fermentation is not available. This review summarized the available literature for the effects of Se on specific rumen microorganisms along with consequences for rumen fermentation and digestibility. Some positive effects on total VFA, the molar proportion of propionate, acetate to propionate ratio, ruminal NH3-N, pH, enzymatic activity, ruminal microbiome composition, and digestibility were recorded. Because Se nanoparticles (SeNPs) were more effective than other forms of Se, more studies are needed to compare the effectiveness of synthetic SeNPs and lactic acid bacteria enriched with sodium selenite as a biological source of SeNPs and probiotics. Future studies also need to evaluate the effect of dietary Se on methane emissions.
Jan. 2022, Research paper (scientific journal), joint, 8, 1, DOI(公開)(r-map) - Abnormal cleavage is involved in the self-correction of bovine preimplantation embryos
Nagai, Hiroki; Okada, Mai; Nagai, Yoko; Sakuraba, Yoshiyuki; Okae, Hiroaki; Suzuki, Ryosuke; Sugimura, Satoshi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
ACADEMIC PRESS INC ELSEVIER SCIENCE
Chromosome instability leading to aneuploidy during early cleavage is well known in humans and cattle. Partial compaction (PC), which occurs only in some blastomeres, is suggested as a self-correction mechanism through which human embryos avoid aneuploid mosaicism. Partially compacted embryos show abnormal cleavages more frequently during early development; however, the mechanism by which blastomeres are excluded has not been elucidated. Here, we confirmed PC in approximately half of the tested bovine embryos, similar to that in human embryos. DNA sequencing of single-cell and intact embryos revealed that the morulae that excluded some blastomeres had euploidy, but many of the excluded blastomeres had aneuploidy. Time-lapse imaging of zygotes without the zona pellucida revealed that the excluded blastomeres underwent reverse and direct cleavages, which are abnormal cleavages, more frequently than the blastomeres involved in compaction. These results suggest the potential role of abnormal cleavage in the self-correction mechanism during the development of mammalian preimplantation embryos. (c) 2021 Elsevier Inc. All rights reserved.
12 Jul. 2021, Research paper (scientific journal), joint, 562, 0006-291X, DOI(公開)(r-map), 76, 82 - Morphokinetic analysis of pronuclei using time-lapse cinematography in bovine zygotes
Suzuki, Ryosuke; Okada, Mai; Nagai, Hiroki; Kobayashi, Junichi; Sugimura, Satoshi
THERIOGENOLOGY
ELSEVIER SCIENCE INC
The morphokinetics of pronuclei (PN) are considered crucial factors affecting embryogenesis in mammals. Whereas, since bovine zygotes contain a large number of cytosolic lipid droplets, detailed observation of PN has not been performed. In this study, we visualized PN using time-lapse cinematography (TLC) with light microscopy for the first time in delipidated bovine zygotes. The proportions of 0 PN, 1PN, 2PN, and multi-PN in delipidated bovine zygotes were 10.1%, 6.5%, 72.7%, and 10.8%, respectively. Abnormal fertilization, including 1 PN and multi-PN, was observed in 15.6% of blastocysts. The times from IVF to PN appearance, PN fading, and first cleavage in 2 PN bovine zygotes that developed into blastocysts were 10.4, 25.5, and 27.6 h, respectively, which were similar to PN morphokinetics in humans. The 2 PN zygotes showed that the prolonged time from IVF to the appearance of PN and from the fading of PN to the first cleavage negatively affected blastocyst formation. The time from appearance to fading of PN in multi-PN zygotes that developed into blastocysts was longer than that in multi-PN zygotes that did not develop into blastocysts. Besides, among zygotes that developed into blastocysts, the time from appearance to fading of PN in multi-PN zygotes was longer than that in 2 PN and 1 PN zygotes. These results suggest that PN morphokinetic abnormalities are associated with subsequent embryonic development. Observation of PN in bovine zygotes by using non-invasive visible light TLC by delipidation could be a powerful tool to clarify the relationship between PN morphokinetics and developmental competence. (c) 2021 Elsevier Inc. All rights reserved.
May 2021, Research paper (scientific journal), joint, 166, 0093-691X, DOI(公開)(r-map), 55, 63 - Effects of 5-Aminolevulinic Acid as a Supplement on Animal Performance, Iron Status, and Immune Response in Farm Animals: A Review
Hendawy, Amin Omar; Khattab, Mostafa Sayed; Sugimura, Satoshi; Sato, Kan
ANIMALS
MDPI
Simple Summary 5-aminolevulinic acid is an amino acid that promotes the formation of heme-an essential constituent of hemoglobin. It has been recently used as a novel feed supplement to enhance the productivity of farm animals, but the current understanding of its effects on livestock is not clear. We systematically evaluated the literature for the effects of 5-aminolevulinic acid supplementation on animal performance, iron status, and immune response in farm animals. Extensive search of PubMed and Web of Science resulted into 16 eligible controlled trials. Findings revealed that iron status and immunity were most responsive to 5-aminolevulinic acid. Other parameters displayed hardly any tangible effect. Studies were highly heterogeneous (regarding species, dose, treatment duration, use of other supplements), which may limit the conclusion. Standard procedures and outcome measures are needed to confirm the benefits of 5-aminolevulinic acid. Attention should also be paid to any adverse effects. Efforts directed toward enhancing animals' productivity are focused on evaluating the effects of non-traditional feed additives that are safer than antibiotics, which have been banned because of their health hazards. Many studies used an amino acid that contributes to heme biosynthesis, known as 5-aminolevulinic acid (5-ALA), to promote the productivity of farm animals. However, these studies demonstrate inconsistent results. In order to develop a clear understanding of the effects of 5-ALA in farm animals, we comprehensively searched PubMed and Web of Science for studies evaluating 5-ALA effects on the performance, iron status, and immune response of different farm animals. The search retrieved 1369 publications, out of which 16 trials were relevant. The 5-ALA-relevant data and methodological attributes of these trials were extracted/evaluated by two independent researchers, based on a set of defined criteria. Samples were comprised of pigs, chickens, and dairy cows. The 5-ALA doses ranged from 2 mg to 1 g/kg of feed, and treatment duration ranged from 10 to 142 days. Overall, 5-ALA improved iron status in most studies and increased white blood cells count in 3 out of 10 studies, in addition to improving animals' cell-mediated immune response following immune stimulation with lipopolysaccharide. Inconsistent findings were reported for growth performance and egg production; however, a combination of 10 mg/kg of 5-ALA with 500 mg/kg of vitamin C promoted the highest egg production. In addition, 5-ALA improved milk protein concentration. In conclusion, 5-ALA can enhance farm animals' iron status and immune response; however, the heterogeneity of the reviewed studies limits the generalizability of the findings. Standard procedures and outcome measures are needed to confirm the benefits of 5-ALA. Attention should also be paid to any adverse effects.
Aug. 2020, Research paper (scientific journal), joint, 10, 8, 2076-2615, DOI(公開)(r-map) - Seasonal changes in the spermatogenesis of the large Japanese field mice (Apodemus speciosus) controlled by proliferation and apoptosis of germ cells
Ito, Jun; Meguro, Kanna; Komatsu, Kazuki; Ohdaira, Takuya; Shoji, Rina; Yamada, Takahisa; Sugimura, Satoshi; Fujishima, Yohei; Nakata, Akifumi; Fukumoto, Manabu; Miura, Tomisato; Yamashiro, Hideaki
ANIMAL REPRODUCTION SCIENCE
ELSEVIER
The aim of this study was to investigate the proliferation and apoptosis of male germ cells during the seasonal reproductive cycle of the large Japanese field mice (Apodemus speciosus). Male mice residing in their natural habitat were captured in Niigata, Japan. Testis sections were stained with haematoxylin and eosin, and mitotic male germ cells were identified using immunofluorescence staining for proliferating cell nuclear antigen (PCNA). Apoptosis was analysed using terminal deoxynucleotidyl transferase (TdT)-mediated deoxyuridine triphosphate (dUTP) nick end labelling (TUNEL) assay. The phases of spermatogenesis during the seasonal reproductive cycle were classified as active, transitional, and inactive based on the diameter of the seminiferous tubules. The number of PCNA-positive germ cells was less during the inactive than other phases. The percentage of TUNEL-positive germ cells per seminiferous tubule was greater during the inactive than active and transitional phases. Spermatogenesis during the seasonal reproductive cycle is controlled by proliferation and apoptosis in male germ cells. This species of undomesticated mice could be used as an animal model to study spermatogenesis as a valuable indicator of the effects of ecological and anthropogenic factors on animal reproduction.
Mar. 2020, Research paper (scientific journal), joint, 214, 0378-4320, DOI(公開)(r-map) - Effects of 5-aminolevulinic acid supplementation on milk production, iron status, and immune response of dairy cows
Hendawy AO, Shirai M, Takeya H, Sugimura S, Miyanari S, Taniguchi S, Sato K.
Journal of Dairy Science
Dec. 2019, Research paper (scientific journal), joint, 102, 12, DOI(公開)(r-map), 11009, 11015 - A microwell culture system that allows group culture and is compatible with human single media
Ieda, Shoko; Akai, Tomonori; Sakaguchi, Yoko; Shimamura, Sumi; Sugawara, Atsushi; Kaneda, Masahiro; Matoba, Satoko; Kagota, Masanori; Sugimura, Satoshi; Kaijima, Hirotsune
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
SPRINGER/PLENUM PUBLISHERS
A microwell culture system that facilitates group culture, such as well-of-the-well (WOW), improves embryonic development in an individual culture. We examined the effect of WOW on embryonic development in vitro with commercially available human single culture media. Using four different commercial human single culture media, in vitro development and imprinted gene expression of bovine embryos cultured in WOW were compared to droplet culture (one zygote per drop). To determine the effects of microwell and group culture on embryonic development, different numbers of embryos were cultured in droplet or WOW. Diffusion simulation of accumulating metabolites was conducted using the finite volume method. WOW had a positive effect on bovine embryonic development, regardless of the type of single culture media. Imprinted gene expression was not different between droplet- and WOW-derived blastocysts. The microwell and group cultures in WOW showed a significant positive effect on the rate of total blastocysts and the rate of development to the expanded and hatching blastocyst stages. The assumed cumulative metabolite concentration of WOW with one embryo was 1.47 times higher than that of droplet culture with one embryo. Furthermore, the concentration of WOW with three embryos was 1.54 times higher than that of WOW with one embryo. In using human single culture media, a microwell culture system that allows group culture could be a powerful clinical tool for improving the success of assisted reproductive technologies.
Oct. 2018, Research paper (scientific journal), joint, 35, 10, 1058-0468, DOI(公開)(r-map), 1869, 1880 - Effect of pre-in vitro maturation with cAMP modulators on the acquisition of oocyte developmental competence in cattle
Sugimura, Satoshi; Yamanouchi, Tadayuki; Palmerini, Maria Grazia; Hashiyada, Yutaka; Imai, Kei; Gilchrist, Robert B.
JOURNAL OF REPRODUCTION AND DEVELOPMENT
SOCIETY REPRODUCTION & DEVELOPMENT-SRD
The administration of follicle-stimulating hormone (FSH) prior to oocyte retrieval improves oocyte developmental competence. During bovine embryo production in vitro, however, oocytes are typically derived from FSH-unprimed animals. In the current study, we examined the effect of pre-in vitro maturation (IVM) with cAMP modulators, also known as the second messengers of FSH, on the developmental competence of oocytes derived from small antral follicles (2-4 mm) of FSH-unprimed animals. Pre-IVM with N6,2'-O-dibutyryladenosine 3',5'-cyclicmonophosphate (dbcAMP) and 3-isobutyl-1-methylxanthine (IBMX) for 2 h improved the blastocyst formation in oocytes stimulated by FSH or amphiregulin (AREG). Furthermore, pre-IVM enhanced the expression of the FSH- or AREG-stimulated extracellular matrix-related genes HAS2, TNFAIP6, and PTGS2, and epidermal growth factor (EGF)-like peptide-related genes AREG and EREG. Additionally, pre-IVM with dbcAMP and IBMX enhanced the expression of EGFR, and also increased and prolonged cumulus cell-oocyte gap junctional communication. The improved oocyte development observed using the pre-IVM protocol was ablated by an EGF receptor phosphorylation inhibitor. These results indicate that pre-IVM with cAMP modulators could contribute to the acquisition of developmental competence by bovine oocytes from small antral follicles through the modulation of EGF receptor signaling and oocyte-cumulus/cumulus-cumulus gap junctional communication.
Jun. 2018, Research paper (scientific journal), joint, 64, 3, 0916-8818, DOI(公開)(r-map), 233, 241 - Live-cell imaging of nuclear-chromosomal dynamics in bovine in vitro fertilised embryos
Yao, Tatsuma; Suzuki, Rie; Furuta, Natsuki; Suzuki, Yuka; Kabe, Kyoko; Tokoro, Mikiko; Sugawara, Atsushi; Yajima, Akira; Nagasawa, Tomohiro; Matoba, Satoko; Yamagata, Kazuo; Sugimura, Satoshi
SCIENTIFIC REPORTS
NATURE PUBLISHING GROUP
Nuclear/chromosomal integrity is an important prerequisite for the assessment of embryo quality in artificial reproductive technology. However, lipid-rich dark cytoplasm in bovine embryos prevents its observation by visible light microscopy. We performed live-cell imaging using confocal laser microscopy that allowed long-term imaging of nuclear/chromosomal dynamics in bovine in vitro fertilised (IVF) embryos. We analysed the relationship between nuclear/chromosomal aberrations and in vitro embryonic development and morphological blastocyst quality. Three-dimensional live-cell imaging of 369 embryos injected with mRNA encoding histone H2B-mCherry and enhanced green fluorescent protein (EGFP)-alpha-tubulin was performed from single-cell to blastocyst stage for eight days; 17.9% reached the blastocyst stage. Abnormalities in the number of pronuclei (PN), chromosomal segregation, cytokinesis, and blastomere number at first cleavage were observed at frequencies of 48.0%, 30.6%, 8.1%, and 22.2%, respectively, and 13.0%, 6.2%, 3.3%, and 13.4%, respectively, for abnormal embryos developed into blastocysts. A multivariate analysis showed that abnormal chromosome segregation (ACS) and multiple PN correlated with delayed timing and abnormal blastomere number at first cleavage, respectively. In morphologically transferrable blastocysts, 30-40% of embryos underwent ACS and had abnormal PN. Live-cell imaging may be useful for analysing the association between nuclear/chromosomal dynamics and embryonic development in bovine embryos.
10 May 2018, Research paper (scientific journal), joint, 8, 2045-2322, DOI(公開)(r-map) - Follicular guidance for oocyte developmental competence
Sugimura S, Richani D, Gilchrist RB
Animal Reproduction
2018, Research paper (scientific journal), joint, 15, DOI(公開)(r-map), 721, 726 - Selection of viable in vitro-fertilized bovine embryos using time-lapse monitoring in microwell culture dishes
Sugimura, Satoshi; Akai, Tomonori; Imai, Kei
Journal of Reproduction and Development
Society Reproduction & Development-SRD
Conventionally, in vitro-fertilized (IVF) bovine embryos for transfer are morphologically evaluated at day 7-8 of embryo culture. This method is, however, subjective and results in unreliable selection. We previously described a novel selection system for IVF bovine blastocysts for transfer that traces the development of individual embryos with time-lapse monitoring in our specially developed microwell culture dishes (LinKID micro25). The system can noninvasively identify prognostic factors that reflect viability after transfer. By assessing a combination of identified prognostic factors-timing of the first cleavage; number of blastomeres at the end of the first cleavage; and number of blastomeres at the onset of lag-phase, which results in temporary developmental arrest during the fourth or fifth cell cycle-the pregnancy rate was improved over using conventional morphological evaluation. Time-lapse monitoring with LinKID micro25 could facilitate objective and reliable selection of healthy IVF bovine embryos. Here, we review the novel bovine embryo selection system that allows for prediction of viability after transfer.
Aug. 2017, Research paper (scientific journal), joint, 63, 4, 0916-8818, 353, 357 - Cacao bean husk: an applicable bedding material in dairy free-stall barns
Yajima, Akira; Owada, Hisashi; Kobayashi, Suguru; Komatsu, Natsumi; Takehara, Kazuaki; Ito, Maria; Matsuda, Kazuhide; Sato, Kan; Itabashi, Hisao; Sugimura, Satoshi; Kanda, Shuhei
Asian-Australasian Journal of Animal Sciences
Asian-Australasian Assoc Animal Production Soc
Objective: The objectives of the study were to assess the effect of cacao bean husk as bedding material in free-stall barn on the behavior, productivity, and udder health of dairy cattle, and on the ammonia concentrations in the barn. Methods: Four different stall surfaces (no bedding, cacao bean husk, sawdust, and chopped wheat straw) were each continuously tested for a period of 1 week to determine their effects on nine lactating Holstein cows housed in the free-stall barn with rubber matting. The lying time and the milk yield were measured between d 4 and d 7. Blood samples for plasma cortisol concentration and teat swabs for bacterial counts were obtained prior to morning milking on d 7. The time-averaged gas-phase ammonia concentrations in the barn were measured between d 2 and d 7. Results: The cows spent approximately 2 h more per day lying in the stalls when bedding was available than without bedding. The milk yield increased in the experimental periods when cows had access to bedding materials as compared to the period without bedding. The lying time was positively correlated with the milk yield. Bacterial counts on the teat ends recorded for cows housed on cacao bean husk were significantly lower than those recorded for cows housed without bedding. Ammonia concentration under cacao bean husk bedding decreased by 6%, 15%, and 21% as compared to no bedding, sawdust, and chopped wheat straw, respectively. The cortisol concentration was lowest in the period when cacao bean husk bedding was used. We observed a positive correlation between the ammonia concentrations in the barn and the plasma cortisol concentrations. Conclusion: Cacao bean husk is a potential alternative of conventional bedding material, such as sawdust or chopped wheat straw, with beneficial effects on udder health and ammonia concentrations in the barns.
Jul. 2017, Research paper (scientific journal), joint, 30, 7, 1011-2367, DOI(公開)(r-map), 1048, 1053 - Transcriptomic signature of the follicular somatic compartment surrounding an oocyte with high developmental competence
Sugimura, Satoshi; Kobayashi, Norio; Okae, Hiroaki; Yamanouchi, Tadayuki; Matsuda, Hideo; Kojima, Takumi; Yajima, Akira; Hashiyada, Yutaka; Kaneda, Masahiro; Sato, Kan; Imai, Kei; Tanemura, Kentaro; Arima, Takahiro; Gilchrist, Robert B.
Scientific Reports
Nature Publishing Group
During antral folliculogenesis, developmental competence of prospective oocytes is regulated in large part by the follicular somatic component to prepare the oocyte for the final stage of maturation and subsequent embryo development. The underlying molecular mechanisms are poorly understood. Oocytes reaching the advanced stage of follicular growth by administration of exogenous follicle-stimulating hormone (FSH) possess higher developmental competence than oocytes in FSH-untreated smaller follicles. In this study, the transcriptomic profile of the cumulus cells from cows receiving FSH administration (FSH-priming) was compared, as a model of high oocyte competence, with that from untreated donor cows (control). Ingenuity Pathway Analysis showed that cumulus cells receiving FSH-priming were rich in down-regulated transcripts associated with cell movement and migration, including the extracellular matrix-related transcripts, probably preventing the disruption of cell-to-cell contacts. Interestingly, the transcriptomic profile of up-regulated genes in the control group was similar to that of granulosa cells from atretic follicles. Interferon regulatory factor 7 was activated as the key upstream regulator of FSH-priming. Thus, acquisition of developmental competence by oocytes can be ensured by the integrity of cumulus cells involved in cell-to-cell communication and cell survival, which may help achieve enhanced oocyte-somatic cell coupling.
Jul. 2017, Research paper (scientific journal), joint, 7, 2045-2322, DOI(公開)(r-map) - Development of a one-run real-time PCR detection system for pathogens associated with bovine respiratory disease complex
Kishimoto, Mai; Tsuchiaka, Shinobu; Rahpaya, Sayed Samim; Hasebe, Ayako; Otsu, Keiko; Sugimura, Satoshi; Kobayashi, Suguru; Komatsu, Natsumi; Nagai, Makoto; Omatsu, Tsutomu; Naoi, Yuki; Sano, Kaori; Okazaki-Terashima, Sachiko; Oba, Mami; Katayama, Yukie; Sato, Reiichiro; Asai, Tetsuo; Mizutani, Tetsuya
Journal of Veterinary Medical Science
Japan Soc Vet Sci
Bovine respiratory disease complex (BRDC) is frequently found in cattle worldwide. The etiology of BRDC is complicated by infections with multiple pathogens, making identification of the causal pathogen difficult. Here, we developed a detection system by applying TaqMan real-time PCR (Dembo respiratory-PCR) to screen a broad range of microbes associated with BRDC in a single run. We selected 16 bovine respiratory pathogens (bovine viral diarrhea virus, bovine coronavirus, bovine parainfluenza virus 3, bovine respiratory syncytial virus, influenza D virus, bovine rhinitis A virus, bovine rhinitis B virus, bovine herpesvirus 1, bovine adenovirus 3, bovine adenovirus 7, Mannheimia haemolytica, Pasteurella multocida, Histophilus somni, Trueperella I pyogenes, Mycoplasma bovis and Ureaplasma diversum) as detection targets and designed novel specific primer-probe sets for nine of them. The assay performance was assessed using standard curves from synthesized DNA. In addition, the sensitivity of the assay was evaluated by spiking solutions extracted from nasal swabs that were negative by Dembo respiratory-PCR for nucleic acids of pathogens or synthesized DNA. All primer-probe sets showed high sensitivity. In this study, a total of 40 nasal swab samples from cattle on six farms were tested by Dembo respiratory-PCR. Dembo respiratory-PCR can be applied as a screening system with wide detection targets.
Mar. 2017, Research paper (scientific journal), joint, 79, 3, 0916-7250, DOI(公開)(r-map), 517, 523 - Extending prematuration with cAMP modulators enhances the cumulus contribution to oocyte antioxidant defence and oocyte quality via gap junctions.
Li HJ, Sutton-McDowall ML, Wang X, Sugimura S, Thompson JG, Gilchrist RB
Human Reproduction
Apr. 2016, Research paper (scientific journal), joint, 31, 4, 810, 21 - Oocyte maturation and quality: role of cyclic nucleotides.
Gilchrist RB, Luciano AM, Richani D, Zeng HT, Wang X, Vos MD, Sugimura S, Smitz J, Richard FJ, Thompson JG.
Reproduction
Mar. 2016, joint, 152, 5, R143, 57 - Development of a novel detection system for microbes from bovine diarrhea by real-time PCR.
Tsuchiaka S, Masuda T, Sugimura S, Kobayashi S, Komatsu N, Nagai M, Omatsu T, Furuya T, Oba M, Katayama Y, Kanda S, Yokoyama T, Mizutani T.
The Journal of Veterinary Medical Science
Mar. 2016, Research paper (scientific journal), joint, 78, 3, 383, 9 - Whole genome analysis of Japanese bovine toroviruses reveals natural recombination between porcine and bovine toroviruses.
Ito M, Tsuchiaka S, Naoi Y, Otomaru K, Sato M, Masuda T, Haga K, Oka T, Yamasato H, Omatsu T, Sugimura S, Aoki H, Furuya T, Katayama Y, Oba M, Shirai J, Katayama K, Mizutani T, Nagai M.
Infection, Genetics and Evolution
Mar. 2016, Research paper (scientific journal), joint, 38, 90, 5 - Electron probe X-ray microanalysis of boar and inobuta testes after the Fukushima accident.
Yamashiro H, Abe Y, Hayashi G, Urushihara Y, Kuwahara Y, Suzuki M, Kobayashi J, Kino Y, Fukuda T, Tong B, Takino S, Sugano Y, Sugimura S, Yamada T, Isogai E, Fukumoto M
Journal of Radiation Research
Dec. 2015, Research paper (scientific journal), joint, 56, Suppl1, 42, 47 - Cumulin, an oocyte-secreted heterodimer of the transforming growth factor-β family, is a potent activator of granulosa cells and improves oocyte quality.
Mottershead DG, Sugimura S, Al-Musawi SL, Li JJ, Richani D, White MA, Martin GA, Trotta AP, Ritter LJ, Shi J, Mueller TD, Harrison CA, Gilchrist RB
Journal of Biological Chemistry
Sep. 2015, Research paper (scientific journal), joint, 290, 39, 24007, 24020 - Promotion of EGF receptor signaling improves the quality of low developmental competence oocytes.
Sugimura S, Ritter LJ, Rose RD, Jeremy JG, Smitz J, Mottershead DG, Gilchrist RB
Developmental Biology
Jul. 2015, Research paper (scientific journal), joint, 403, 2, 139, 149 - Oocyte induction of EGF responsiveness in somatic cells is associated with the acquisition of porcine oocyte developmental competence.
Ritter LJ, Sugimura S, Gilchrist RB
Endocrinology
Jun. 2015, Research paper (scientific journal), joint, 156, 6, 2299, 2312 - Modifications of human growth differentiation factor 9 to improve the generation of embryos from low competence oocytes.
Li JJ, Sugimura S, Mueller TD, White MA, Martin GA, Ritter LJ, Liang XY, Gilchrist RB, Mottershead DG
Molecular Endocrinology
Jan. 2015, Research paper (scientific journal), joint, 29, 1, 40, 52 - Amphiregulin co-operates with bone morphogenic protein 15 to increase bovine oocyte developmental competence: effects on gap junction-mediated metabolites supply.
Sugimura S, Ritter LJ, Sutton-McDowall ML, Mottershead DG, Thompson JG, Gilchrist RB
Molecular Human Reproduction
Jun. 2014, Research paper (scientific journal), joint, 20, 6, 499, 513 - Optimizing production of in vivo-matured oocytes from superstimulated Holstein cows for in vitro production of embryos using X-sorted sperm.
Matoba S, Yoshioka H, Matsuda H, Sugimura S, Aikawa Y, Ohtake M, Hashiyada Y, Seta T, Nakagawa K, Lonergan P, Imai K
Journal of Dairy Science
Feb. 2014, Research paper (scientific journal), joint, 97, 2, 743, 753 - Effect of embryo density on in vitro development and gene expression in bovine in vitro-fertilized embryos cultured in a microwell system.
Sugimura S, Akai T, Hashiyada Y, Aikawa Y, Ohtake M, Matsuda H, Kobayashi S, Kobayashi E, Konishi K, Imai K
Journal of Reproduction and Development
Mar. 2013, Research paper (scientific journal), joint, 59, 2, 115, 122 - Oxidative phosphorylation-linked respiration in individual bovine oocytes.
Sugimura S, Matoba M, Hashiyada Y, Aikawa Y, Ohtake M, Matsuda H, Kobayashi S, Konishi K, Imai K
Journal of Reproduction and Development
Dec. 2012, Research paper (scientific journal), joint, 58, 6, 636, 641 - Promising system for selecting healthy in vitro–fertilized embryos in cattle.
Sugimura S, Akai T, Hashiyada Y, Somfai T, Inaba Y, Hirayama, M., Yamanouchi T, Matsuda, H, Kobayashi S, Aikawa Y, Ohtake M, Kobayashi E, Konishi K, Imai K
PLoS ONE
May 2012, Research paper (scientific journal), joint, 7, 5, e36626 - Follicular growth-stimulated cows provide favorable oocytes for producing cloned embryos.
Sugimura S, Kobayashi S, Hashiyada Y, Ohtake M, Kaneda M, Yamanouchi T, Matsuda H, Aikawa Y, Watanabe S, Nagai T, Kobayashi E, Konishi K, Imai K
Cellular Reprogramming
Feb. 2012, Research paper (scientific journal), joint, 14, 1, 29, 37 - DNA methylation analysis on satellite I region in blastocysts obtained from somatic cell cloned cattle.
Yamanaka K, Kaneda M, Inaba Y, Saito K, Kubota K, Sakatani M, Sugimura S, Imai K, Watanabe S, Takahashi M
Animal Science Journal
Aug. 2011, Research paper (scientific journal), joint, 82, 4, 523, 530 - Improving the quality of miniature pig somatic cell nuclear transfer blastocysts: aggregation of SCNT embryos at the four-cell stage.
Terashita Y, Sugimura S, Kudo Y, Amano R, Hiradate Y, Sato E
Reproduction in Domestic Animal
Apr. 2011, Research paper (scientific journal), joint, 46, 2, 189, 196 - Time-lapse cinematography-compatible polystyrene-based microwell culture system: a novel tool for tracking the development of individual bovine embryos.
Sugimura S, Akai T, Somfai T, Hirayama M, Aikawa Y, Ohtake M, Hattori H, Kobayashi S, Hashiyada Y, Konishi K, Imai K
Biology of Reproduction
Dec. 2010, Research paper (scientific journal), joint, 83, 6, 970, 978 - Anomalous oxygen consumption in porcine somatic cell nuclear transfer embryos.
Sugimura S, Yokoo M, Yamanaka K, Kawahara M, Moriyasu S, Wakai T, Nagai T, Abe H, Sato E
Cellular Reprogramming
Aug. 2010, Research paper (scientific journal), joint, 12, 4, 463, 474 - Lactate and adenosine triphosphate in the extender enhance the cryosurvival of rat epididymal sperm.
Yamashiro H, Toyomizu M, Kikusato M, Toyama N, Sugimura S, Hoshino Y, Abe H, Moisyadi S, Sato E
Journal of the American Association for Laboratory Animal Science
Mar. 2010, Research paper (scientific journal), joint, 49, 2, 160, 166 - Early metaphase II oocytes treated with dibutyryl cyclic adenosine monophosphate provide suitable recipient cytoplasm for the production of miniature pig somatic cell nuclear transfer embryos.
Sugimura S, Yamanaka K, Kawahara M, Wakai T, Yokoo M, Sato E
Animal Science Journal
Feb. 2010, Research paper (scientific journal), joint, 81, 1, 48, 57 - Acetylation level of histone H3 in early embryonic stages affects subsequent development of miniature pig somatic cell nuclear transfer embryos.
Yamanaka K, Sugimura S, Wakai T, Kawahara M, Sato E
Journal of Reproduction and Development
Dec. 2009, Research paper (scientific journal), joint, 55, 6, 638, 644 - Interspecies somatic cell nucleus transfer with porcine oocytes as recipients: A novel bioassay system for assessing the competence of canine somatic cells to develop into embryos.
Sugimura S, Narita K, Yamashiro H, Sugawara A, Shoji T, Terashita Y, Nishimori K, Konno T, Yoshida M, Sato E
Theriogenology
Sep. 2009, Research paper (scientific journal), joint, 72, 4, 549, 559 - Development and spindle formation in rat somatic cell nuclear transfer (SCNT) embryos in vitro using porcine recipient oocytes.
Sugawara A, Sugimura S, Hoshino Y, Sato E
Zygote
Aug. 2009, Research paper (scientific journal), joint, 17, 3, 195, 202 - Difference in sensitivity to culture condition between in vitro fertilized and somatic cell nuclear transfer embryos in pigs.
Yamanaka K, Sugimura S, Wakai T, Kawahara M, Sato E
Journal of Reproduction and Development
Jun. 2009, Research paper (scientific journal), joint, 55, 3, 299, 304 - Production of viable cloned miniature pig embryos using oocytes derived from domestic pig ovaries.
Wakai T, Sugimura S, Yamanaka K, Kawahara M, Sasada H, Tanaka H, Ando A, Kobayashi E, Sato E
Cloning and Stem Cells
Jun. 2008, Research paper (scientific journal), joint, 10, 2, 249, 262 - Effect of cytochalasins B and D on the developmental competence of somatic cell nuclear transfer embryos in miniature pigs.
Sugimura S, Kawahara M, Wakai T, Yamanaka K, Sasada H, Sato E
Zygote
May 2008, Research paper (scientific journal), joint, 16, 2, 153, 159 - Induction of estrus in pubertal miniature gilts.
Wakai T, Tanaka H, Yamanaka K, Sugimura S, Sasada H, Kawahara M, Kobayashi E, Sato E
Animal Reproduction Science
Jan. 2008, Research paper (scientific journal), joint, 103, 1-2, 193, 198 - Trehalose enhanced the freezability of Poodle dog sperm collected by an artificial vagina (AV).
Yamashiro H, Narita K, Sugimura S, Han YJ, Sugawara A, Morohaku K, Nakazato F, Konno T, Yoshida M, Sato E
Animal Reproduction Science
Nov. 2007, Research paper (scientific journal), joint, 102, 1-2, 165, 171 - Effect of activation treatments on actin filament distribution and in vitro development of miniature pig somatic cell nuclear transfer embryos.
Yamanaka K, Sugimura S, Wakai T, Shoji T, Kobayashi J, Sasada H, Sato E
Journal of Reproduction and Development
Aug. 2007, Research paper (scientific journal), joint, 53, 4, 791, 800 - Caffeine promotes premature chromosome condensation formation and in vitro development in porcine reconstructed embryos via a high level of maturation promoting factor activity during nuclear transfer.
Kawahara M, Wakai T, Yamanaka K, Kobayashi J, Sugimura S, Shimizu T, Matsumoto H, Kim JH, Sasada H, Sato E
Reproduction
Sep. 2005, Research paper (scientific journal), joint, 130, 3, 351, 357
Presentations
- ウシ体外受精胚の核・染色体異常を生きたまま見分ける新技術
受精卵関連新技術全国会議
28 Feb. 2019, Oral presentation(invited, special) - ウシ体外受精胚の品質評価―IETSの指標だけで本当に大丈夫？ー
第２回日本胚移植技術研究会大会
20 Sep. 2018, Oral presentation(invited, special) - ウシ着床前胚の生育成否予測
第61回日本生殖医学会学術講演会
03 Nov. 2017, Oral presentation(invited, special) - ウシ体外受精胚を用いたLinKIDの有用性評価
マイクロウェル型ディッシュLinKIDが切り開く次世代の胚培養
10 Sep. 2017, Oral presentation(invited, special) - Morphokinetics of preimplantation embryo and the viability
25th International Symposium Morphological Sciences
26 Jul. 2017, Oral presentation(invited, special) - ウシ体外受精胚の生育成否予測
第57回日本卵子学会
14 May 2016, Oral presentation(invited, special) - Selection of healthy bovine IVP embryos for ET
3rd Symposium of the Thai Society for Animal Reproduction
13 Jan. 2016, Oral presentation(invited, special) - ウシ体外生産胚の生育成否予測
新学術領域「着床前ワークショップ」
10 Mar. 2014, Oral presentation(invited, special) - タイムラプスシネマトグラフィを用いたウシ体外生産胚の生育能予測
核移植・受精卵移植全国会議
25 Feb. 2014, Oral presentation(invited, special)
External funds
- 人工知能による牛体外受精卵の自動評価事業
other subsidy, From 01 Apr. 2020, To 31 Mar. 2021 - リキッドバイオプシーによる非侵襲的牛体外受精胚の遺伝子スクリーニング
donation, From 2017, To 2017 - 被災牛における放射線被ばく特異的なバイオマーカーの同定と継世代的影響評価系の確立
cooperative research, From 01 Oct. 2015, To 31 Mar. 2016 - ウシ卵子の発生能獲得機構の解明
donation, From 2015, To 2015
Committee Memberships
- 全国大学附属農場協議会
庶務幹事
From 20230501, To 20250431 - 日本胚移植技術研究会
広報担当幹事
From 20200401, To 20220331 - 日本繁殖生物学会
評議委員
From 20200401, To 20220331 - 日本繁殖生物学会
渉外担当幹事
From 20200401, To 20220331
Media Coverage
- 胃腸に優しい「A2ミルク」生産・・・東京農工大発VB、新技術で役立つ牛群を短期創出
農工大発ベンチャーのPIXTURE（ピクスチャー）は、農工大 杉村智史教授が発明した技術で、社会ニーズに適した「牛群」を創出する事業モデルを確立すると掲載される。また、ピクスチャーは農工大と民間の連携による東京農工大ファンド（TUATファンド）の投資先第1号と紹介される。
ニュースイッチ
From 15 Aug. 2024, To 15 Aug. 2024 - 役立つ牛群短期創出東京農工大発VB「ピクスチャー」体外受精の新技術活用胃腸にやさしい「A2ミルク」生産
農工大発ベンチャーのPIXTURE（ピクスチャー）は、農工大 杉村智史教授が発明した技術で、社会ニーズに適した「牛群」を創出する事業モデルを確立すると掲載される。また、ピクスチャーは農工大と民間の連携による東京農工大ファンド（TUATファンド）の投資先第1号と紹介される。
日刊工業新聞
From 08 Aug. 2024, To 08 Aug. 2024 - 【神への挑戦】グレーの胚 命になるか 人知の向かう先は 第2部 生命科学iPS細胞を分化胚モデル「本物」に接近 人工子宮で培養も再現性 9割超
農工大の杉村智史教授が、ウシの胚を人工子宮で長期培養する研究に取り組んでいると紹介される。
毎日新聞
From 25 Apr. 2024, To 25 Apr. 2024 - これからの農場教育を考えるシンポジウム 19日に開催 全国大学附属農場協議会
シンポジウムの総合司会として杉村智史氏（東京農工大学教授）が登壇すると紹介される。
農業協同組合新聞
From 16 May 2023, To 16 May 2023 - 生きたまま染色体を診た受精卵から健康な子牛を産ませることに成功
東京農工大学、近畿大学、扶桑薬品工業、農研機構の研究グループが細胞を生きたまま連続観察する技術により、染色体分配の様子を捉えた体外受精卵から、健康な講師を産ませることに成功したと紹介される。
肉牛ジャーナル
From 01 Jul. 2022, To 01 Jul. 2022 - Chromosomal errors that develop early lead to embryonic loss in assisted reproductive technology
“Chromosome aneuploidy is thought to occur due to chromosome segregation errors that develop early, which may cause embryonic loss,” said researcher Satoshi Sugimura of the Institute of Agriculture at the Tokyo University of Agriculture and Technology in Tokyo, Japan.
EurekAlert!／Phys.Org
From 22 Jun. 2022, To 22 Jun. 2022 - 健全な牛受精卵選別 大学研究グループなど細胞観察技術を応用
日本農業新聞
From 16 Aug. 2018, To 16 Aug. 2018 - 業界短信
牛受精卵の染色体異常を生きたまま見分ける技術を開発
畜産コンサルタント
From 01 Jun. 2018, To 01 Jun. 2018 - ウシの受精卵、生きたまま見分け和牛増産や乳牛安定的確保に期待 ほか
東京農工大学、近畿大学、扶桑薬品、農研機構が、牛の良好な受精卵を生きたまま見分ける技術を開発したことが紹介される。
全国農業新聞／WEB／日本経済新聞／WEB
From 25 May 2018, To 28 May 2018 - ウシ受精卵の異常光らせて見分ける
日本経済新聞
From 18 May 2018, To 18 May 2018 - Beefing Up IVF SuccessScientists in Japan have used live-cell imaging to identify bovine IVF embryos without chromosomal abnormalities and increase the success of cow pregnancies.
In this study, a research group led by Dr. Satoshi Sugimura of the Tokyo University of Agriculture and Technology has successfully identified bovine IVF embryos bearing chromosomal abnormalities by long term live-cell imaging with fluorescence confocal microscopy.
Asian Scientist
From 17 May 2018, To 17 May 2018 - 牛の受精卵を生きたまま選別し良好なものを選ぶ技術を開発、東京農工大
「ライブセルイメージング技術」によって、生きた状態の牛受精卵を選別し、染色体異常などを発見する技法を東京農工大学大学院農学研究院生物生産科学部門・杉村智史テニュアトラック特任准教授らの共同研究グループが開発したことが紹介される。
財経新聞／Livedoorニュース／Biglobeニュース
From 14 May 2018, To 14 May 2018 - 良好なウシ受精卵選別
農工大などイメージング技術応用
化学工業日報
From 14 May 2018, To 14 May 2018 - Identification of bovine IVF embryos without chromosome abnormalities by live-cell imaging
Research groups of Dr. Satoshi Sugimura (Tokyo University of Agriculture and Technology), Dr. Kazuo Yamagata (Kindai University), Mr. Tatsuma Yao (FUSO Pharmaceutical Industries, Ltd.), and Dr. Satoko Matoba (NARO), now report in the journal Scientific Reports, that successful nonvisible selection of bovine IVF embryos without chromosomal abnormalities by long term "live cell imaging" with fluorescence confocal microscopy.
EurekAlart
From 10 May 2018, To 10 May 2018