研究者データベース
倉科 佑太KURASHINA Yutaクラシナ ユウタ
| ■所属部署名 | 工学研究院 先端機械システム部門 | |||
| ■職名 | 准教授 | |||
Last Updated :2025/06/18
業績情報
氏名・連絡先
氏名
クラシナ ユウタ, 倉科 佑太, KURASHINA Yuta
主たる所属・職名
工学研究院 先端機械システム部門, 准教授
その他の所属
担当授業科目
科学研究費助成事業
- 基盤研究（A）
三次元組織の高度成熟化を自律的に達成する知能化培養システム基盤の創出
自 2023年, 至 2023年 - 挑戦的研究（萌芽）
超音波を用いたポリフェノール配合マイクロニードル薬剤投与の高速化
自 2022年, 至 2023年 - 国際共同研究加速基金（国際共同研究強化(B)）
表面弾性波を用いたin situ波形測定による細胞組織の成熟評価AIシステムの構築
自 2022年, 至 2025年 - 基盤研究(B)
がん診断治療への最適化を目指したマルチコア構造磁性ナノ粒子の磁化応答モデル構築
自 2022年, 至 2022年 - 挑戦的研究（萌芽）
がん転移に関わる細胞分化機構解明を目的とした細胞-細胞間引張強度測定技術の創成
自 2022年, 至 2022年 - 基盤研究(B)
重畳化した超音波照射による生体高分子の経皮薬剤送達システムの構築
自 2021年, 至 2023年
論文
- Hydrogel-Sheathed Hipsc-Derived Heart Microtissue Enables Anchor-Free Contractile Force Measurement
Kurashina, Yuta; Fukada, Keisuke; Itai, Shun; Akizuki, Shuichi; Sato, Ryo; Masuda, Akari; Tani, Hidenori; Fujita, Jun; Fukuda, Keiichi; Tohyama, Shugo; Onoe, Hiroaki
ADVANCED SCIENCE
WILEY
In vitro reconstruction of highly mature engineered heart tissues (EHTs) is attempted for the selection of cardiotoxic drugs suitable for individual patients before administration. Mechanical contractile force generated in the EHTs is known to be a critical indicator for evaluating the EHT response. However, measuring contractile force requires anchoring the EHT in a tailored force-sensing cell culture chamber, causing technical difficulties in the stable evaluation of contractile force in long-term culture. This paper proposes a hydrogel-sheathed human induced pluripotent stem cell (hiPSC)-derived heart microtissue (H3M) that can provide an anchor-free contractile force measurement platform in commonly used multi-well plates. The contractile force associated with tissue formation and drug response is calculated by motion tracking and finite element analysis on the bending angle of the hydrogel sheath. From the experiment of the drug response, H3M is an excellent drug screening platform with high sensitivity and early testing capability compared to conventionally anchored EHT. This unique platform would be useful and versatile for regenerative therapy and drug discovery research in EHT.
2023年12月, 研究論文（学術雑誌）, 共同, 10, 35, DOI(公開)(r-map) - Spatiotemporal single-cell tracking analysis in 3D tissues to reveal heterogeneous cellular response to mechanical stimuli
Kasahara, Keitaro; Muramatsu, Jumpei; Kurashina, Yuta; Miura, Shigenori; Miyata, Shogo; Onoe, Hiroaki
SCIENCE ADVANCES
AMER ASSOC ADVANCEMENT SCIENCE
Mechanical stimuli have been recognized as important for tissue maturation, homeostasis and constructing engineered three-dimensional (3D) tissues. However, we know little about the cellular mechanical response in tissues that could be considerably heterogeneous and spatiotemporally dynamic due to the complex structure of tissues. Here, we report a spatiotemporal single-cell tracking analysis of in vitro 3D tissues under mechanical stretch, to reveal the heterogeneous cellular behavior by using a developed stretch and optical live imaging system. The system could affect the cellular orientation and directly measure the distance of cells in in vitro 3D myoblast tissues (3DMTs) at the single-cell level. Moreover, we observed the spatiotemporal heterogeneous cellular locomotion and shape changes under mechanical stretch in 3DMTs. This single-cell tracking analysis can become a principal method to investigate the heterogeneous cellular response in tissues and provide insights that conventional analyses have not yet offered.
2023年10月13日, 研究論文（学術雑誌）, 共同, 9, 41, 2375-2548, DOI(公開)(r-map) - Controlled release of adeno-associated virus from alginate hydrogel microbeads with enhanced sensitivity to ultrasound
Takatsuka, Shuhei; Kubota, Takeshi; Kurashina, Yuta; Kurihara, Sho; Hirabayashi, Motoki; Fujioka, Masato; Okano, Hirotaka James; Onoe, Hiroaki
BIOTECHNOLOGY AND BIOENGINEERING
WILEY
Adeno-associated virus (AAV)-based gene therapy holds promise as a fundamental treatment for genetic disorders. For clinical applications, it is necessary to control AAV release timing to avoid an immune response to AAV. Here we propose an ultrasound (US)-triggered on-demand AAV release system using alginate hydrogel microbeads (AHMs) with a release enhancer. By using a centrifuge-based microdroplet shooting device, the AHMs encapsulating AAV with tungsten microparticles (W-MPs) are fabricated. Since W-MPs work as release enhancers, the AHMs have high sensitivity to the US with localized variation in acoustic impedance for improving the release of AAV. Furthermore, AHMs were coated with poly-l-lysine (PLL) to adjust the release of AAV. By applying US to the AAV encapsulating AHMs with W-MPs, the AAV was released on demand, and gene transfection to cells by AAV was confirmed without loss of AAV activity. This proposed US-triggered AAV release system expands methodological possibilities in gene therapy.
2023年08月, 研究論文（学術雑誌）, 共同, 120, 8, 0006-3592, DOI(公開)(r-map), 2371, 2377 - Schwann cell-encapsulated chitosan-collagen hydrogel nerve conduit promotes peripheral nerve regeneration in rodent sciatic nerve defect models
Takeya, Hiroaki; Itai, Shun; Kimura, Hiroo; Kurashina, Yuta; Amemiya, Tsuyoshi; Nagoshi, Narihito; Iwamoto, Takuji; Sato, Kazuki; Shibata, Shinsuke; Matsumoto, Morio; Onoe, Hiroaki; Nakamura, Masaya
SCIENTIFIC REPORTS
NATURE PORTFOLIO
Chitosan has various tissue regeneration effects. This study was designed to investigate the nerve regeneration effect of Schwann cell (SC)-encapsulated chitosan-collagen hydrogel nerve conduit (CCN) transplanted into a rat model of sciatic nerve defect. We prepared a CCN consisting of an outer layer of chitosan hydrogel and an inner layer of collagen hydrogel to encapsulate the intended cells. Rats with a 10-mm sciatic nerve defect were treated with SCs encapsulated in CCN (CCN+), CCN without SCs (CCN-), SC-encapsulated silicone tube (silicone+), and autologous nerve transplanting (auto). Behavioral and histological analyses indicated that motor functional recovery, axonal regrowth, and myelination of the CCN+ group were superior to those of the CCN- and silicone+ groups. Meanwhile, the CCN- and silicone+ groups showed no significant differences in the recovery of motor function and nerve histological restoration. In conclusion, SC-encapsulated CCN has a synergistic effect on peripheral nerve regeneration, especially axonal regrowth and remyelination of host SCs. In the early phase after transplantation, SC-encapsulated CCNs have a positive effect on recovery. Therefore, using SC-encapsulated CCNs may be a promising approach for massive peripheral nerve defects.
2023年07月24日, 研究論文（学術雑誌）, 共同, 13, 1, 2045-2322, DOI(公開)(r-map) - Mechanical effect of reconstructed shapes of autologous ossicles on middle ear acoustic transmission
Asakura, Takumi; Ito, Ryuya; Hirabayashi, Motoki; Kurihara, Sho; Kurashina, Yuta
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
FRONTIERS MEDIA SA
Conductive hearing loss is caused by a variety of defects, such as chronic otitis media, osteosclerosis, and malformation of the ossicles. In such cases, the defective bones of the middle ear are often surgically reconstructed using artificial ossicles to increase the hearing ability. However, in some cases, the surgical procedure does not result in increased hearing, especially in a difficult case, for example, when only the footplate of the stapes remains and all of the other bones are destroyed. Herein, the appropriate shapes of the reconstructed autologous ossicles, which are suitable for various types of middle-ear defects, can be determined by adopting an updating calculation based on a method that combines numerical prediction of the vibroacoustic transmission and optimization. In this study, the vibroacoustic transmission characteristics were calculated for bone models of the human middle ear by using the finite element method (FEM), after which Bayesian optimization (BO) was applied. The effect of the shape of artificial autologous ossicles on the acoustic transmission characteristics of the middle ear was investigated with the combined FEM and BO method. The results suggested that the volume of the artificial autologous ossicles especially has a great influence on the numerically obtained hearing levels.
2023年06月22日, 研究論文（学術雑誌）, 共同, 11, 2296-4185, DOI(公開)(r-map) - Can nanoparticles enhance drug-delivery performance of hydrogels?
Rossi, Filippo; Kurashina, Yuta; Onoe, Hiroaki
NANOMEDICINE
FUTURE MEDICINE LTD
2023年04月, 研究論文（学術雑誌）, 共同, 18, 8, 1743-5889, DOI(公開)(r-map), 653, 657 - A Novel Rat Model of Embolic Cerebral Ischemia Using a Cell-Implantable Radiopaque Hydrogel Microfiber
Komatsu, Teppei; Ohta, Hiroki; Takakura, Naoki; Hata, Junichi; Kitagawa, Tomomichi; Kurashina, Yuta; Onoe, Hiroaki; Okano, Hirotaka James; Iguchi, Yasuyuki
TRANSLATIONAL STROKE RESEARCH
SPRINGER
The failure of neuroprotective treatment-related clinical trials, including stem cell therapies, may be partially due to a lack of suitable animal models. We have developed a stem cell-implantable radiopaque hydrogel microfiber that can survive for a long time in vivo. The microfiber is made of barium alginate hydrogel containing zirconium dioxide, fabricated in a dual coaxial laminar flow microfluidic device. We aimed to develop a novel focal stroke model using this microfiber. Using male Sprague-Dawley rats (n=14), a catheter (inner diameter, 0.42 mm; outer diameter, 0.55 mm) was navigated from the caudal ventral artery to the left internal carotid artery using digital subtraction angiography. A radiopaque hydrogel microfiber (diameter, 0.4 mm; length, 1 mm) was advanced through the catheter by slow injection of heparinized physiological saline to establish local occlusion. Both 9.4-T magnetic resonance imaging at 3 and 6 h and 2% 2,3,5-triphenyl tetrazolium chloride staining at 24 h after stroke model creation were performed. Neurological deficit score and body temperature were measured. The anterior cerebral artery-middle cerebral artery bifurcation was selectively embolized in all rats. Median operating time was 4 min (interquartile range [IQR], 3-8 min). Mean infarct volume was 388 mm(3) (IQR, 354-420 mm(3)) at 24 h after occlusion. No infarction of the thalamus or hypothalamus was seen. Body temperature did not change significantly over time (P = 0.204). However, neurological deficit scores before and at 3, 6, and 24 h after model creation differed significantly (P < 0.001). We present a novel rat model of focal infarct restricted to the middle cerebral artery territory using a radiopaque hydrogel microfiber positioned under fluoroscopic guidance. By comparing the use of stem cell-containing versus non-containing fibers in this stroke model, it would be possible to determine the efficacy of pure cell transplantation in treating stroke.
2023年03月03日, 研究論文（学術雑誌）, 共同, 1868-4483, DOI(公開)(r-map) - Acoustic-responsive carbon dioxide-loaded liposomes for efficient drug release
Orita, Yasuhiko; Shimanuki, Susumu; Okada, Satoshi; Nakamura, Kentaro; Nakamura, Hiroyuki; Kitamoto, Yoshitaka; Shimoyama, Yusuke; Kurashina, Yuta
ULTRASONICS SONOCHEMISTRY
ELSEVIER
The role of liposomes as drug carriers has been investigated. Ultrasound-based drug release methods have been developed for on-demand drug delivery. However, the acoustic responses of current liposome carriers result in low drug release efficiency. In this study, CO2-loaded liposomes were synthesized under high pressure from supercritical CO2 and irradiated with ultrasound at 237 kHz to demonstrate their superior acoustic respon-siveness. When liposomes containing fluorescent drug models were irradiated with ultrasound under acoustic pressure conditions that are safe for the human body, CO2-loaded liposomes synthesized using supercritical CO2 had 17.1 times higher release efficiency than liposomes synthesized using the conventional Bangham method. In particular, the release efficiency of CO2-loaded liposomes synthesized using supercritical CO2 and mono-ethanolamine was 19.8 times higher than liposomes synthesized using the conventional Bangham method. These findings on the release efficiency of acoustic-responsive liposomes suggest an alternative liposome synthesis strategy for on-demand release of drugs by ultrasound irradiation in future therapies.
2023年03月, 研究論文（学術雑誌）, 共同, 94, 1350-4177, DOI(公開)(r-map) - Near-Infrared-Triggered On-Demand Controlled Release of Adeno-Associated Virus from Alginate Hydrogel Microbeads with Heat Transducer for Gene Therapy
Takatsuka, Shuhei; Kubota, Takeshi; Kurashina, Yuta; Onoe, Hiroaki
SMALL
WILEY
Gene therapy using adeno-associated virus (AAV) has potential as a radical treatment modality for genetic diseases such as sensorineural deafness. To establish clinical applications, it is necessary to avoid immune response to AAV by controlled release system of AAV. Here, a near-infrared (NIR)-triggered on-demand AAV release system using alginate hydrogel microbeads with a heat transducer is proposed. By using a centrifuge-based microdroplet shooting device, the microbeads encapsulating AAV with Fe3O4 microparticles (Fe3O4-MPs) as a heat transducer are fabricated. Fe3O4-MPs generated heat by NIR enhanced the diffusion speed of the AAV, resulting in the AAV being released from the microbeads. By irradiating the microbeads encapsulating fluorescent polystyrene nanoparticles (FP-NPs) (viral model) with NIR, the fluorescence intensity decreased only for FP-NPs with a diameter of 20 nm and not for 100 or 200 nm, confirming that this system can release virus with a diameter of several tens of nanometers. By irradiating NIR to the AAV-encapsulating microbeads with Fe3O4-MPs, the AAV is released on demand, and gene transfection to cells by AAV is confirmed without loss of viral activity. The NIR-triggered AAV release system proposed in this study increases the number of alternatives for the method of drug release in gene therapy.
2023年02月, 研究論文（学術雑誌）, 共同, 19, 7, 1613-6810, DOI(公開)(r-map) - Synthesis and characterization of pH-responsive ferrogels comprising sulfamethazine-based polymer and magnetic nanoparticles for sensing ammonia gas
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
ELSEVIER
Ferrogels have been widely used in soft actuators and as carriers in drug delivery systems owing to their responsiveness to magnetic stimulus. Herein, a novel ferrogel that exhibits chemically modulated magnetism is synthesized, by dispersing magnetic nanoparticles (MNPs) in a hydrogel produced from a pH-responsive sulfa-methazine-based polymer during polymerization and cross-linking. The MNPs exhibit dynamic rotations or os-cillations in the rheological matrix under alternating current (AC) magnetic fields. The AC magnetization behavior of the incorporated MNPs is modulated by the swelling of the hydrogel in response to changes in pH over the range of 7-12. The ferrogels with larger swelling ratios exhibit enhanced Brownian relaxation during AC magnetization. Based on the pH response of the AC magnetization, the detection of ammonia gas is investigated using the ferrogel as a sensing label, and the sensitivity of 5.3 x 10-6 mol/L or lower has been achieved. Therefore, the as-prepared ferrogel is suitable for use as a sensing label in applications such as the sensing of ammonia emitted from human skin for health monitoring.
2023年01月01日, 研究論文（学術雑誌）, 共同, 565, 170201, 0304-8853, DOI(公開)(r-map) - Combined analysis of finite element model and audiometry provides insights into the pathogenesis of conductive hearing loss
Hirabayashi, Motoki; Kurihara, Sho; Ito, Ryuya; Kurashina, Yuta; Motegi, Masaomi; Okano, Hirotaka James; Yamamoto, Yutaka; Kojima, Hiromi; Asakura, Takumi
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
FRONTIERS MEDIA SA
The middle ear transmits sound to the inner ear via vibrations in the eardrum and ossicles, and damage to the middle ear results in conductive hearing loss. Although conductive hearing loss can be corrected by surgery, the currently available clinical investigations cannot always diagnose the ossicular chain pathology underlying the conductive hearing loss, and even intraoperative findings can be equivocal. Acoustic analysis using finite element models (FEMs) can simulate the sound pressure change at an arbitrary site for each frequency. FEMs are used in acoustic engineering to simulate the frequency-dependent sound pressure distribution at discrete cells in a simulated model and analyze the effects of specific parameters on the audiogram. However, few reports have compared the numerical results obtained using FEMs with data from clinical cases. We used FEMs to simulate audiograms of the air-bone gap (ABG) for various ossicular chain defects and compared these with preoperative audiograms obtained from 44 patients with a normal tympanic membrane who had otosclerosis, middle ear malformations or traumatic ossicular disruption. The simulated audiograms for otosclerosis and attic fixation of the malleus-incus complex both exhibited an up-slope but could be distinguished from each other based on the ABG at 1000 Hz. The simulated audiogram for incudostapedial joint discontinuity exhibited a peak at around 750 Hz and a down-slope above 1000 Hz. In general, the simulated audiograms for otosclerosis, attic fixation and incudostapedial joint discontinuity were consistent with those obtained from clinical cases. Additional simulations indicated that changes in ossicular mass had relatively small effects on ABG. Furthermore, analyses of combination pathologies suggested that the effects of one defect on ABG were added to those of the other defect. These FEM-based findings provide insights into the pathogenesis of conductive hearing loss due to otosclerosis, middle ear malformations and traumatic injury.
2022年09月02日, 研究論文（学術雑誌）, 共同, 10, 2296-4185, DOI(公開)(r-map) - Transdermal delivery of bFGF with sonophoresis facilitated by chitosan nanocarriers
Xie, Xue; Kurashina, Yuta; Matsui, Makoto; Nomoto, Takahiro; Itoh, Munenari; Okano, Hirotaka J.; Nakamura, Kentaro; Nishiyama, Nobuhiro; Kitamoto, Yoshitaka
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
ELSEVIER
The basic fibroblast growth factor (bFGF) is a potent angiogenic growth factor. Supplemental bFGF is essential for healing damaged skin, but its therapeutic use has been limited owing to its inherent instability. In this study, we propose a transdermal delivery system using sonophoresis along with the use of carboxymethyl chitosan nanocarriers which enables the administration of bFGF over a wide area of skin. The transdermal effect of the low-frequency ultrasound-enhanced delivery system was demonstrated in ex vivo experiments using hairless mouse skin. The subcutaneous administration of chitosan nanoparticles was evaluated by using fluorescencelabeled chitosan. To stably load bFGF into chitosan nanoparticles, a carrier with carboxymethyl chitosan was synthesized under a pH of around 7. Based on the results, we evaluated the effectiveness of transdermal drug delivery using sonophoresis. In skin cryosections, bFGF-loaded carboxymethyl chitosan nanocarriers delivered by ultrasound irradiation were present subcutaneously. We analyzed the bFGF content in skin tissue by ELISA and found that bFGF penetration in skin irradiated by ultrasound with nanocarriers. Penetration of bFGF-leaded carboxymethyl chitosan nanocarriers by ultrasound was significantly higher than that by ultrasound irradiation alone. Our results lay the groundwork for further utilization of polymeric nanocarriers using sonophoresis for the administration of biomacromolecules.
2022年09月, 研究論文（学術雑誌）, 共同, 75, 1773-2247, DOI(公開)(r-map) - Vascular embolization of radiopaque hydrogel microfiber using ultra-minimally invasive technique for stage-adjustable renal failure model
Takakura, Naoki; Ohta, Hiroki; Komatsu, Teppei; Kurashina, Yuta; Hiroka, Yuya; Okano, Hirotaka J.; Onoe, Hiroaki
MATERIALS & DESIGN
ELSEVIER SCI LTD
Animal pathology models play an important role in elucidating pathology, evaluating drug efficacy, and studying therapeutic. This paper presents the creation of rats' renal failure model by embolizing the renal artery using radiopaque hydrogel microfibers. By using a dual coaxial laminar flow microfluidic device, barium alginate gel microfibers containing zirconia particles were fabricated. Since the zirconia particles are radiopaque, the microfiber can be delivered and embolized while confirming the position of the microfiber in real-time under X-ray imaging. The delivery of microfibers through a catheter into the renal artery of rats to create a renal failure model was tested. The radiopaque microfibers were visualized by X-ray imaging when delivered by a catheter. Furthermore, the microfibers remained stable for 2 weeks after delivery. In addition, by adjusting the number of microfibers, two different rat models with severe and mild renal failure conditions were created. The proposed delivery of radiopaque hydrogel microfibers to create an embolization model is expected to be an effective approach to control the degree of symptoms and elucidate the pathology. (c) 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
2022年07月, 研究論文（学術雑誌）, 共同, 219, 0264-1275, DOI(公開)(r-map) - A novel fabrication process of up-scalable microfiber-shaped tendon-like tissue with high cell density for uniformed macroscale assembly
Fukada, Keisuke; Tachibana, Koji; Kurashina, Yuta; Kaneko, Yosuke; Matsumoto, Tatsuaki; Miyamoto, Takeshi; Niki, Yasuo; Nakamura, Masaya; Onoe, Hiroaki
BIOTECHNOLOGY AND BIOENGINEERING
WILEY
This paper describes up-scalable microfiber-shaped tissues for macroscale tendon tissue reconstruction in vitro. C3H10T1/2 cells were encapsulated in a calcium alginate hydrogel microfiber that was fabricated via a double coaxial microfluidic device. The C3H10T1/2 cells gradually merged to construct the microfiber-shaped tendon-like tissue. Our microfiber-shaped tendon-like tissues were alive and maintained their microfiber-shaped morphology over 600 days. Immunostaining and real-time quantitative polymerase chain reaction analyses showed that our fabricated microfiber-shaped tendon-like tissue properly expressed tenomodulin and the orientation of the filaments of actin, which are one of the characteristics of tendon tissue in vivo. Furthermore, a macroscale tendon tissue assembly with similar to 1 cm in length and similar to 200 mu m in thickness was successfully constructed by bundling the microfiber-shaped tendon-like tissues together. This feature enabled us to fabricate a macroscale tendon tissue with uniform cell distribution. We believe that our fabricated microfiber-shaped tendon-like tissue would be a suitable strategy to reconstruct tendon tissue in vitro for the treatments of tendon-related injuries.
2022年05月, 研究論文（学術雑誌）, 共同, 119, 5, 0006-3592, DOI(公開)(r-map), 1327, 1336 - QUANTITATIVE ANALYSIS OF ACOUSTIC PRESSURE FOR SONOPHORESIS AND ITS EFFECT ON TRANSDERMAL PENETRATION
Kurashina, Yuta; Asano, Risa; Matsui, Makoto; Nomoto, Takahiro; Ando, Keita; Nakamura, Kentaro; Nishiyama, Nobuhiro; Kitamoto, Yoshitaka
ULTRASOUND IN MEDICINE AND BIOLOGY
ELSEVIER SCIENCE INC
Ultrasound facilitates the penetration of macromolecular compounds through the skin and offers a promising non-invasive technique for transdermal delivery. However, technical difficulties in quantifying ultrasound-related parameters have restricted further analysis of the sonophoresis mechanism. In this study, we devise a bolt-clamped Langevin transducer-based sonophoresis device that enables us to measure with a thin lead zirconate titanate (PZT) sensor. One-dimensional acoustic theory accounting for wave interaction at the skin interface indicates that the acoustic pressure and cavitation onset on the skin during sonophoresis are sensitive to the subcutaneous support, meaning that there is a strong need to perform the pressure measurement in an experimental environment replacing the human body. From a series of the experiments with our new device, the transdermal penetration of polystyrene, silica and gold nanoparticles is found to depend on the size and material of the particles, as well as the hardness of the subcutaneous support material. We speculate from the acoustic pressure measurement that the particles' penetration results from the mechanical action of cavitation.(E-mail: kurashina@mac.titech.ac.jp) (c) 2022 World Federation for Ultrasound in Medicine & Biology. All rights reserved.
2022年05月, 研究論文（学術雑誌）, 共同, 48, 5, 0301-5629, DOI(公開)(r-map), 933, 944 - Effect of the area of a lithium niobate transducer on the efficiency of ultrasonic atomization driven by resonance vibration
Yoshioka, Keisuke; Kurashina, Yuta; Ogawa, Ami; Asakura, Takumi
ULTRASONICS SONOCHEMISTRY
ELSEVIER
In recent years, individual control of one's personal environment has been drawing increasing attention due to the growing interest in health care. Wearable devices are especially useful because of their controllability regardless of location. Humidity is one of the inevitable factors in the personal environment as a preventive against infectious diseases. Although atomization devices are commonly used as a method of humidity control, at present, there are no wearable humidity control devices. Vibration of a lithium niobate (LN) device in the thickness mode is a promising piezoelectric method for miniaturization of atomization devices for humidity control. To miniaturize the atomization device, the transducer size needs to be small not so much as to decrease the atomization efficiency. However, the effect of the device area on the atomization efficiency of LN at a size suitable for mounting in wearable devices has not been studied. Here, we conducted an atomization demon-stration of LN devices with different sizes to evaluate particle size and atomization efficiency. Furthermore, to reveal the relationship between vibration behavior and atomization efficiency, resonance vibration in the MHz frequency band was evaluated by the finite element method and an impedance analyzer. The results showed that the peak size of water particles atomized by each device was in the range of 3.2 to 4.2 mu m, which is smaller than particles produced by typical piezoelectric ceramics. Moreover, the best LN size for efficient atomization was found to be 8 mm x 10 mm among the five LN device sizes used in experiments. From the relationship between vibration behavior and atomization efficiency, the size of the transducer was suggested to affect the vibration mode. The obtained result suggested that the LN device is suitable for small wearable nebulizer devices.
2022年05月, 研究論文（学術雑誌）, 共同, 86, 1350-4177, DOI(公開)(r-map)
研究発表、招待講演等
- Microsphere-like AAV carrier using hydrogel
AAV researcher meet up in Kitasato
2023年11月20日, 口頭発表（招待・特別） - Heart regeneration with iPS cell-derived cardiomyocytes contributed by using ultrasound and hydrogel
International Conference on Precision Engineering and Sustainable Manufacturing
2023年07月19日, 口頭発表（招待・特別）
委員歴
- 精密工学会 次世代センサ・アクチュエータ委員会
運営委員
自 202304, 至 202403 - 日本機械学会 機械力学・計測制御分野
若手交流実行委員長
自 202204, 至 202208 - International Workshop on Piezoelectric Materials and Applications in Actuators
実行委員
自 202204, 至 202210
メディア報道
- 【科学技術・大学】慶大など心筋細胞 薬物評価で新技術チューブ内で培養 必要細胞数３ケタ減
慶応大学と農工大の倉科先生らの研究チームが心筋細胞への薬物評価基盤技術を開発したと紹介される。
日刊工業新聞
自 2023年11月17日, 至 2023年11月17日
受賞
- The 37th IEEE International conference on micro electro mechanical systems (MEMS)
Outstanding Student Oral Presentation Award Finalist
2024年01月25日 - PRESM 2023
Young Researcher Award（International Conference on Precision Enginneering and Sustainable Manufacturing）
若手研究者として精密工学および持続可能な製造の分野に顕著な貢献をした功績を称え、授与される。
2023年07月14日